13 mai 2022 · 2022 opponents Home Los Angeles Rams : The 49ers fell to the eventual Super Bowl champion Rams in the NFC Championship Game, but still swept L.A. in the regular-season series. 12 mai 2023 · According to the strength of schedule (SOS) system that factors the 2022 records of all teams by NFL research, the 49ers are ranked with the 15th-toughest lineup of opponents in the league.