2021 · Dr. Jeffrey Juchau agrees 9 thanks A 34-year-old member asked: Can i take mucinex (guaifenesin) dm and vicks nyquil together? Dr. Joseph Woods answered Pathology 30 years experience Should be OK.: Mucinex (guaifenesin) is an expectorant called guanefesin while nyquil is a combination of pain reliever, cough suppressant, antihistamine/hypnotic, a.